Decidual and peripheral blood TCRαβ+CD3+CD4-CD8- double negative regulatory T cells in early pregnancy subjects and unexplained recurrent spontaneous abortion patients
نویسندگان
چکیده
Accumulating evidences have demonstrated that TCRαβ+CD3+CD4-CD8NK1.1-double negative regulatory T cells (DN Tregs) are highly potent immune suppressors and play an important role in down regulating immune responses in autoimmunity, transplant rejection, graft-versus-host disease (GvHD). Whether human DN Tregs play a role in maternal-fetal immunological tolerance hasn’t been reported yet. In the present study, to explore the possible role of human DN Tregs in unexplained recurrent spontaneous abortion (URSA), we compare the frequency and function of peripheral and/or decidual DN Tregs of 22 women with normal history of reproduction, 31 normal early pregnant women and 42 URSA patients through flow Cytometry and cell proliferation assays. The proportion of DN Tregs in decidua was significantly higher than peripheral blood both in URSA patients and normal early pregnant women. It is the proportion but not the suppressive ability of DN Tregs decreased in peripheral blood and decidua of URSA patients than normal early pregnant women. Our result suggests that human DN Tregs enrich in decidua and may contribute to the mechanisms mediating maternal-fetal immunological tolerance and may be involved in protection the fetus during pregnancy in human. Also, DN Tregs may serve as a novel target in URSA treatment.
منابع مشابه
Comparison of the Percentages of Peripheral Blood CD4+ CD25+ T Lymphocytes in Recurrent Abortion and Normal Pregnancy
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Correlation between unexplained recurrent spontaneous abortion with CD4+CD25+ regulatory T-cell and killer cell immunoglobulin-like receptor levels
The present study investigated the correlation between unexplained recurrent spontaneous abortion (URSA) with CD4+CD25+ regulatory T-cell (Treg) and killer cell immunoglobulin-like receptor (KIR)-2DL1 levels. A total of 76 URSA patients were enrolled (35 without pregnancy, Group A, and 41 with early abortion, Group B). Additionally, 30 patients who received a regular abortion as planned (Group ...
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تاریخ انتشار 2016